Rational design of low-cost and high-efficient non-precious-metal catalysts for oxygen reduction reaction (ORR) has drawn tremendous attention. Herein, we report a facile template-sacrificing strategy to synthesize N-doped hierarchically porous graphitic layers wrapped iron carbide (Fe3C@NPGL). Cost-effective graphitic carbon nitride (g-C3N4) combined with dopamine were used as dual-nitrogen-source which provide more active sites for ORR. By virtue of abundant Fe-N coordination sites and unique porous structure of NPGL, the as-fabricated Fe3C@NPGL exhibits excellent ORR performances with a half-wave potential of 0.87&nbsp;V, a limited current density of 6.3&nbsp;mA&nbsp;cm-2, and a low peroxide yield ( less then 2.5%), which outperform commercial Pt/C and most of the reported non-precious-metal catalysts. This work provides a feasible strategy to design novel ORR electrocatalysts. An alarming increase in bacterial resistance towards various types of antibiotics makes it imperative to design alternate or combinational therapies to treat stubborn bacterial infections. In this perspective, emerging tools like nanozymes, nanomaterials with biological enzyme like characteristics, are being utilised to control infections caused by bacterial pathogens. Among several nanozymes used for antibacterial applications, Fe3O4 nanoparticles (NP) received great attention due to their effective peroxidase like activity. The pH dependent peroxidase activity of Fe3O4 NP results in generation of OH radical via the unique Fenton chemistry of iron. However, their pH dependent activity is restricted to acidic environment and dramatic loss in antibacterial activity is observed at near neutral pH. Here we describe a novel strategy to overcome the pH lacunae of citrate coated Fe3O4 NP by utilizing adenosine triphosphate disodium salt (ATP) as a synergistic agent to accelerate the OH radical production and restore its antibacterial activity over a wide range of pH. This synergistic combination (30&nbsp;?g/mL Fe3O4 NP and 2.5&nbsp;mM ATP) shows a high bactericidal activity against both gram positive (B. subtilis) and gram negative (E. coli) bacterial strains, in presence of H2O2, at neutral pH. The synergistic effect (Fe3O4 NP&nbsp;+&nbsp;ATP) is determined from the viability assessment and membrane damage studies and is further confirmed by comparing the concentration of generated OH radicals. Over all, this study illustrates ATP assisted and OH-mediated bactericidal activity of Fe3O4 nanozyme at near neutral pH. In this work, flower-like Bi2MoO6 nanoparticles grown on FTO substrates were firstly fabricated using a seed-free hydrothermal method. The Bi2MoO6 nanoflowers exhibited, to the best of our knowledge, higher photoelectrochemical (PEC) performances than other previously reported morphologies. It is generally accepted that the formation of type-I heterostructures is unfavorable for PEC applications. Nevertheless, in this work, we have successfully constructed a novel type-I architecture with numerous electron transport channels. In this unique Bi2MoO6/BiVO4 structure, BiVO4 films were continuously distributed on both the surfaces and the interstices of Bi2MoO6 nanoflowers. Interconnected BiVO4 nanoparticles could intimately contact with FTO substrates and thus constitute the electron transport channels, which could promptly transfer electrons to FTO substrates. Simultaneously, a cocatalyst of g-C3N4 was modified on the surfaces of BiVO4 to capture the photogenerated holes. As a result, the PEC activities of Bi2MoO6/BiVO4 heterostructures were significantly improved due to the enhanced charge carriers separation efficiency. The special design of electron transport channel may provide a universal strategy to address the intrinsic drawbacks of type-I heterostructures. Fluorescence imaging and magnetic resonance imaging have been research hotspots for adjuvant therapy and diagnosis. However, traditional fluorescent probes or contrast agents possess insurmountable weaknesses. In this work, we reported the preparation of dual-mode probes based on mesoporous silica nanomaterials (MSNs), which were doped with an aggregation-induced emission (AIE) dye and Gd3+ through a direct sol-gel method. https://www.selleckchem.com/products/golvatinib-e7050.html In this system, the obtained materials emitted strong red fluorescence, in which the maximum emission wavelength was located at 669&nbsp;nm, and could be applied as effective fluorescence probes for fluorescence microscopy imaging. Furthermore, the introduction of Gd3+ made the nanoparticles effective contrast agents when applied in contrast-enhanced magnetic resonance (MR) imaging because they could improve the contrast of MR imaging. The excellent biocompatibility of these nanoparticles, as demonstrated via a typical CCK-8 assay, and their performance in fluorescence cell imaging and MR imaging shows their potential for applications in biomedical imaging. OBJECTIVE To investigate the effectiveness of a guided self-help exercise program on swallowing, speech, and shoulder problems in patients treated with total laryngectomy (TL). MATERIALS AND METHODS This randomized controlled trial included patients treated with TL in the last 5&nbsp;years. Patients were randomized into the intervention group (self-help exercise program with flexibility, range-of-motion and lymphedema exercises and self-care education program) or control group (self-care education program). Both groups completed measurements before and 3 and 6-months after randomization. The primary outcome was swallowing problems (SWAL-QOL). Secondary outcomes were speech problems (SHI), shoulder problems (SDQ), self-management (patient activation PAM) and health-related quality of life (HRQOL EORTC QLQ-C30/H&amp;N35). Adherence was defined as moderate-high in case a patient exercised &gt;1 per day. Linear mixed model analyses were conducted to investigate the effectiveness of the intervention and to investigate whether neck dissection, treatment indication (primary/salvage TL), time since treatment, severity of problems, and preferred format (online/booklet) moderated the effectiveness. RESULTS Moderate-high adherence to the exercise program was 59%. The intervention group (n&nbsp;=&nbsp;46) reported less swallowing and communication problems over time compared to the control group (n&nbsp;=&nbsp;46) (p-value&nbsp;=&nbsp;0.013 and 0.004). No difference was found on speech, shoulder problems, patient activation and HRQOL. Time since treatment moderated the effectiveness on speech problems (p-value&nbsp;=&nbsp;0.025) patients within 6&nbsp;months after surgery benefitted most from the intervention. Being treated with a neck dissection, treatment indication, severity of problems and format did not moderate the effectiveness. CONCLUSION The guided self-help exercise program improves swallowing and communication. TRIAL REGISTRATION NTR5255.